L’Oreal Wrinkle Decrease Collagen Filler offers an alternative to surgery for those particularly problematic areas. L’Oreal Wrinkle Decrease Collagen Filler’s exclusively patented biospheres can inflate up to nine times once in contact with the liquid that is naturally close to the skin’s surface. They make the skin seem more fluid and wrinkles look firmer and flatter. Directions of Use: Focus on your most obvious wrinkles, then smooth a light layer over the rest of the skin to even it out. Use at least once a day, but preferably during both your morning and evening skincare routine to optimise results.