Isotonix OPC-3 is an isotonic-capable food supplement that is made from a combination of bilberry, grape seed, red wine, pine bark extracts and citrus extract bioflavonoids. Isotonix OPC-3 contains isotonic-capable Pycnogenol , renowned for its extensive clinical research with more than 120 studies published in peer-reviewed medical journals. Oligomeric proanthocyanidins OPCs are bioflavonoids complex organic plant compounds found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be many times more powerful than vitamin C and vitamin E. Isotonix OPC-3 contains OPCs from grape seed extract, red wine extract, bilberry extract, Pycnogenol from pine bark and citrus fruit. Our grape seed extract is a superior source of OPC, containing 92 percent of active ingredients with pine bark containing 84 percent of active OPC ingredients. The red wine extract contains flavonoids called leucocyanidins from the skin of red grapes. These are the three best sources of oligomeric proanthocyanidins available. Over 20,000 different flavonoids have been discovered, of which a select few are water-soluble and easily absorbed by the body. Isotonix OPC-3 contains the top three of the most bioavailable and potent forms of OPCs. Pycnogenol in Isotonix OPC-3 is the most clinically researched and potent bioflavonoid. Isotonic, which means same pressure, bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body’s tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in isotonic fluids. Isotonix dietary supplements are delivered in a solution similar in constitution to the body’s own naturally produced isotonic fluids. This similarity of pH and osmotic pressure means that the body has less work to do in order to convert the solution into a state ready for maximum absorption - greatly decreasing the amount of time and work necessary to absorb a supplement. The isotonic state of the suspension allows nutrients to pass into the small intestine and be effectively absorbed into the blood stream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results. Pycnogenol is registered in the US.